EPANUTIN INJECTION PDF

Phenytoin Injection prescription and dosage sizes information for physicians and healthcare professionals. Pharmacology, adverse reactions, warnings and side. Page 1. Page 4. Malta ADR Reporting website: adrportal 5. How to store Epanutin RMP The storage of Epanutin RMP will not be . Epanutin Injection is used for Seizure, Migraine, Cardiac arrhythmias and other conditions. Epanutin Injection may also be used for purposes not listed in this.

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Tell your doctor if your condition persists or worsens. Check with your doctor or pharmacist if you are on long-term antiepileptic medication, have a history of osteoporosis, or take steroids. Generic Name and Formulations: Subcutaneous or perivascular injection should be avoided because of the highly alkaline nature of the solution. Haemorrhagic syndrome has been reported in neonates born from epileptic mothers receiving phenytoin.

Eye disorders Common blurred vision, visual impairment Uncommon diplopia Ear and labyrinth disorders Common tinnitus, vertigo Uncommon hypoacusis Cardiac disorders Uncommon cardiac arrest Not known severe cardiotoxic reactions with atrial and ventricular conduction depression including bradycardia and all degrees of heart blockventricular fibrillation and cardiovascular collapse see section 4.

Table 7 displays dosing information epwnutin status epilepticus maintenance dose in children. For Dose reduction in the Elderly or patients with Renal or Hepatic impairment, please see guidance towards the end of this section. A reduction in the rate of administration or discontinuation of dosing may be necessary see section 4. Parenteral Epanutin is suitable for use as long as it remains free of haziness and precipitate.

Check them now, epaanutin if you are going to continue to be given Epanutin RMP or any other form of phenytoin. Serum levels of phenytoin in the therapeutic range cannot be rapidly achieved by this method. Mean total phenytoin half-life values Pro-Epanutin should not be used in women of childbearing potential, women planning pregnancy, and pregnant women, except where there is a clinical need and when possible, the woman is made aware of the risks of taking fosphenytoin during pregnancy.

Epanitin is completely bioavailable following IM administration of Pro-Epanutin. The amount and concentration of fosphenytoin is always expressed in terms of mg PE. Each injection or infusion of intravenous Epanutin should be preceded and followed by an injection of sterile saline through the same needle or catheter to avoid local venous irritation due to alkalinity of the solution see section 4.

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For time periods less than one week, the patient switched from intramuscular administration should receive one half the original oral dose for the same period of time the patient received Epanutin intramuscularly. These have been reported very rarely. The lethal dose in children is not known.

Table 10 displays dosing information for the temporary substitution of oral phenytoin sodium in children. Serum level determinations for phenytoin are especially helpful when possible drug interactions are suspected. Plasma phenytoin concentrations should be determined at the first sign of acute toxicity see section epanutij.

Make sure you are very clear about the risks and benefits of being given Epanutin Epanuin. In females, altered oestrous cycles, prolonged gestation, and delayed mating were observed.

Epanutiin should not be discontinued prior to reassessment of the treatment. The conversion half-life of fosphenytoin to phenytoin is approximately 15 minutes. Large amounts of phosphate, delivered rapidly, could potentially cause hypocalcaemia with paraesthesia, muscle spasms and seizures.

Pro-Epanutin Concentrate for Infusion / Solution for Injection

In considering the use of Epanutin intravenously in the management of status epilepticus in epanugin, the following information should be weighed in assessing the risks and the benefits. Although phosphate and formaldehyde formate have potentially important biological effects, these effects typically occur at concentrations considerably in excess of those obtained when Pro-Epanutin is administered under conditions of use recommended in this labelling.

Patients should seek medical advice from their physician immediately when observing any indicative signs or symptoms. Severe cardiovascular reactions including atrial and ventricular conduction depression, ventricular fibrillation, asystole and fatalities have been reported following phenytoin and fosphenytoin administration. Drugs that may increase or decrease phenytoin concentrations listed by likely mechanism: Fosphenytoin displaces phenytoin from protein binding sites.

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Nausea, vomiting, lethargy, tachycardia, bradycardia, asystole, cardiac arrest, hypotension, syncope, hypocalcaemia, metabolic acidosis and death have epaanutin reported in cases of overdosage with Pro-Epanutin.

In view of isolated reports associating phenytoin with exacerbation of porphyria, caution should be exercised in epnautin this medication in patients suffering from this disease. Marketing authorisation holder 8. The sensations are not consistent with the signs of an allergic reaction and may be avoided or minimised by using a slower rate of IV infusion or by temporarily stopping the infusion.

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What Epanutin RMP is and what it is used for This medicine is a solution for injection or infusion containing phenytoin, which belongs to a group of medicines called antiepileptic drugs. Fosphenytoin sodium injection is a prodrug intended for parenteral administration; its active metabolite onjection phenytoin.

Dose mg phenytoin sodium. There have been reports of decreased bone mineral density, osteopenia, osteoporosis and fractures in patients on long-term therapy with phenytoin. After injection phenytoin is distributed into body fluids including the cerebrospinal fluid CSF. Epanutin Injection may also be used for purposes not listed in this medication guide.

Epanutin Ready Mixed Parenteral

If you suspect that you or anyone else who may have overdosed injecion Epanutin Injectionplease go to the emergency department of the closest hospital or nursing home. Although resolution of symptoms may occur without treatment, skin necrosis and limb ischemia have occurred that required surgical interventions and, in rare cases, amputation.

The serum level achieved by a given dose is therefore also subject to wide variation. Detailed information related to Epanutin Injection’s uses, composition, dosage, side effects and reviews is listed below.

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Phenytoin Injection Dosage & Rx Info | Uses, Side Effects – MPR

epauntin After administration of a loading dose, maintenance doses should typically be started at the next identified dosing interval. Therefore, breast-feeding is not recommended for women receiving Pro-Epanutin. There are many drugs which may increase or decrease plasma phenytoin concentrations. Pregnancy, breast-feeding and fertility If you do get pregnant while you are given Epanutin RMP you must tell your doctor straight away. Dermatological manifestations sometimes accompanied by fever have included scarlatiniform or morbilliform rashes.

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